MK-28

CAT: 0804-HY-137207-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No

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CAT#:0804-HY-137207-02Size:10 mM - 1 mL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

MK-28 is a potent and selective PERK activator. MK-28 exhibits remarkable pharmacokinetic properties and high BBB penetration in mice[1].

CAS Number

864388-65-8

UNSPSC

12352005

Target

PERK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mk-28.html

Purity

99.88

Solubility

DMSO : 12.5 mg/mL (ultrasonic)

Smiles

OC1=CC=C(C=C1O)/C=N/N(C2=NC(C3=CC=CC=C3)=CC(C4=CC=CC=C4)=N2)C

Molecular Formula

C24H20N4O2

Molecular Weight

396.44

References & Citations

[1]Javier Ganz, et al. A novel specific PERK activator reduces toxicity and extends survival in Huntington's disease models. Sci Rep. 2020 Apr 23;10 (1) :6875.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

CID 135715675

CAS Number	864388-65-8
PubChem CID	135715675
IUPAC Name	4-[(E)-[(4,6-diphenylpyrimidin-2-yl)-methylhydrazinylidene]methyl]benzene-1,2-diol
Molecular Formula	C24H20N4O2
Molecular Weight	396.4
XLogP	4.9
Topological Polar Surface Area	81.8
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Heavy Atom Count	30
Formal Charge	0
Complexity	521

SMILES

CN(C1=NC(=CC(=N1)C2=CC=CC=C2)C3=CC=CC=C3)/N=C/C4=CC(=C(C=C4)O)O

InChI

InChI=1S/C24H20N4O2/c1-28(25-16-17-12-13-22(29)23(30)14-17)24-26-20(18-8-4-2-5-9-18)15-21(27-24)19-10-6-3-7-11-19/h2-16,29-30H,1H3/b25-16+

InChIKey

GKOVHCFOVLXKFL-PCLIKHOPSA-N

Chemical Structure

2D Structure

CAS: 864388-65-8

CID: 135715675

Formula: C24H20N4O2

MW: 396.4

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	396.4
XLogP3	4.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Exact Mass	396.15862589
Monoisotopic Mass	396.15862589
Topological Polar Surface Area	81.8 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	521
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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BUP08627-01	MK-28
324068-01	MK
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MBS131418	Doravirine (MK-1439; MK1439; MK 1439)
456310-01	MK 677
MKB78162-01	MK-0674
MBS5753488	MK 0893
SLB91045-01	MK-6892
RGC58140-01	MK 8318

MK-28

Chemical Information

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