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Thalidomide-4-OH

CAT: 0804-HY-103596-01Size: 5 gDry Ice: NoHazardous: No
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CAT#:0804-HY-103596-01Size:5 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Thalidomide-4-OH (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) can be connected to the ligand for protein by a linker to form PROTACs[1].
CAS Number
5054-59-1
Product Name Alternative
Cereblon ligand 2; E3 ligase Ligand 2
UNSPSC
12352005
Hazard Statement
H302, H361, H373
Target
Apoptosis; Autophagy; Ligands for E3 Ligase
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/E3_ligase_Ligand_2.html
Purity
99.92
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O
Molecular Formula
C13H10N2O5
Molecular Weight
274.23
Precautions
H302, H361, H373
References & Citations
[1]Marks MG, et al. Effects of putative hydroxylated thalidomide metabolites on blood vessel density in the chorioallantoic membrane (CAM) assay and on tumor and endothelial cell proliferation. Biol Pharm Bull. 2002 May;25 (5) :597-604.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon

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