Thalidomide 4-fluoride

• Description :

  Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966) [1].

• Product Name Alternative :

  Cereblon ligand 4; E3 ligase Ligand 4

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Apoptosis; Autophagy; Ligands for E3 Ligase

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Autophagy; PROTAC

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/E3_ligase_Ligand_4.html

• Purity :

  99.94

• Solubility :

  DMSO : 200 mg/mL (ultrasonic)

• Smiles :

  O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3F)=O

• Molecular Formula :

  C13H9FN2O4

• Molecular Weight :

  276.22

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Nello Mainolfi, et al. Irak degraders and uses thereof. US20190192668A1.|[2]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512 (7512) :49-53.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Cereblon

• CAS Number :

  [835616-60-9]