Thalidomide 4-fluoride

• UNSPSC Description:

  Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966)[1].

• Target Antigen:

  Apoptosis; Autophagy; Ligands for E3 Ligase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Autophagy;PROTAC

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/E3_ligase_Ligand_4.html

• Purity:

  99.94

• Solubility:

  DMSO : 200 mg/mL (ultrasonic)

• Smiles:

  O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3F)=O

• Molecular Weight:

  276.223

• References & Citations:

  [1]Nello Mainolfi, et al. Irak degraders and uses thereof. US20190192668A1.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  835616-60-9