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Thalidomide-1-Me,4-OH

CAT: 0931-T206197-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T206197-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2244568-06-5
Target
Ligand for E3 Ligase
Related Pathways
PROTAC
Bioactivity
Thalidomide-1-Me,4-OH is an alcohol-like analogue of Thalidomide. Thalidomide acts as a ligand for E3 ubiquitin ligase, which ubiquitinates proteins, leading to their eventual degradation via proteolysis.
Smiles
O=C1C=2C=CC=C(O)C2C(=O)N1C3C(=O)N(C(=O)CC3)C
Molecular Formula
C14H12N2O5
Molecular Weight
288.255
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

4-Hydroxy-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
CAS Number2244568-06-5
PubChem CID139346652
IUPAC Name4-hydroxy-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
Molecular FormulaC14H12N2O5
Molecular Weight288.25
XLogP0.5
Topological Polar Surface Area95
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Heavy Atom Count21
Formal Charge0
Complexity531
SMILES
CN1C(=O)CCC(C1=O)N2C(=O)C3=C(C2=O)C(=CC=C3)O
InChI
InChI=1S/C14H12N2O5/c1-15-10(18)6-5-8(13(15)20)16-12(19)7-3-2-4-9(17)11(7)14(16)21/h2-4,8,17H,5-6H2,1H3
InChIKey
DYFPLJSQQAPUSL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-Hydroxy-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
CAS: 2244568-06-5
CID: 139346652
Formula: C14H12N2O5
MW: 288.25
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight288.25
XLogP30.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Exact Mass288.07462149
Monoisotopic Mass288.07462149
Topological Polar Surface Area95 Ų
Heavy Atom Count21
Formal Charge0
Complexity531
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
HY-W441376-01Thalidomide-1-Me,4-OH
HY-W8677044-Me-Thalidomide
MBS5786104Thalidomide-4-OH
GTR19258435-01Thalidomide-4-OH-C11-OH
HY-W460193-01N-Me-Thalidomide 4-fluoride
HY-168964Ethanolamine-Thalidomide-4-OH
HY-W674436-01(S) -Thalidomide-4-OH
HY-W586821-01Thalidomide-1-Me-5-NH2
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HY-161188Thalidomide-O-C4H4-N (Me) -piperidine-C2-OH

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