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9-ING-41

CAT: 0804-HY-113914-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-113914-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
9-ING-41 (Elraglusib) is a maleimide-based ATP-competitive and selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 of 0.71 μM. 9-ING-41 significantly leads to cell cycle arrest, autophagy and apoptosis in cancer cells. 9-ING-41 has anticancer activity and has the potential for enhancing the antitumor effects of chemotherapeutic agents[1][2][3][4].
CAS Number
[1034895-42-5]
Product Name Alternative
Elraglusib
UNSPSC
12352005
Hazard Statement
H301, H311, H331, H341
Target
Apoptosis; Autophagy; GSK-3
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/9-ing-41.html
Purity
99.13
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C(C1=COC2=CC=C(F)C=C12)=C3C4=CN(C)C5=C4C=C6C(OCO6)=C5)NC3=O
Molecular Formula
C22H13FN2O5
Molecular Weight
404.35
Precautions
H301, H311, H331, H341
References & Citations
[1]Ugolkov AV, et al. 9-ING-41, a small-molecule glycogen synthase kinase-3 inhibitor, is active in neuroblastoma. Anticancer Drugs. 2018 Sep;29 (8) :717-724.|[2]Wu X, et al. Targeting glycogen synthase kinase 3 for therapeutic benefit in lymphoma. Blood. 2019 Jul 25;134 (4) :363-373.|[3]Irina N Gaisina, et al. From a natural product lead to the identification of potent and selective benzofuran-3-yl- (indol-3-yl) maleimides as glycogen synthase kinase 3beta inhibitors that suppress proliferation and survival of pancreatic cancer cells. J Med Chem. 2009 Apr 9;52 (7) :1853-63.|[4]Hiroo Kuroki, et al. 9-ING-41, a small molecule inhibitor of GSK-3beta, potentiates the effects of anticancer therapeutics in bladder cancer. Sci Rep. 2019 Dec 27;9 (1) :19977.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
GSK-3β

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