CDK9-IN-41

CAT: 0804-HY-147794-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-147794-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CDK9-IN-41 is a potent CDK9, EGFR, HER2, and COX-2 kinases inhibitor with IC50s of 192.81 nM, 254.03 nM, 238.81 nM, and 775 nM. COX-2-IN-18 exhibits remarkable antitumor activity against leukemia cancer cells, colon cancer cells, melanoma cells, ovarian cells and breast cells[1].
CAS Number
[1038061-96-9]
UNSPSC
12352005
Target
CDK; COX; EGFR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cox-2-in-18.html
Purity
98.84
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=C(CCN2C(SCC)=NC3=C(C=CC=C3)C2=O)C=C1)(N)=O
Molecular Formula
C18H19N3O3S2
Molecular Weight
389.49
References & Citations
[1] El-Azab AS, et al. Antitumor activity, multitarget mechanisms, and molecular docking studies of quinazoline derivatives based on a benzenesulfonamide scaffold: Cell cycle analysis. Bioorg Chem. 2020;104:104345.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK9; COX-2; EGFR/ErbB1/HER1; ErbB2/HER2

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