CHIR-98023

CAT: 0804-HY-126125-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-126125-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CHIR-98023 is a potent, selective and reversible inhibitor of GSK3, with IC50s of 10 nM and 6.7 nM for GSK3α and GSK3β, respectively. CHIR-98023 can improve insulin action and glucose metabolism[1][2].
CAS Number
[252916-76-0]
UNSPSC
12352005
Target
GSK-3
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/chir-98023.html
Solubility
10 mM in DMSO
Smiles
O=[N+](C1=CN=C(NCCNC2=NC=C(C3=NC=CN3)C(C4=CC=C(Cl)C=C4Cl)=N2)C=C1)[O-]
Molecular Formula
C20H16Cl2N8O2
Molecular Weight
471.30
References & Citations
[1]Cline GW, et, al. Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats. Diabetes. 2002 Oct;51 (10) :2903-10.|[2]Hu M, et, al. Role of GSK-3beta activation and alpha7 nAChRs in Abeta (1-42) -induced tau phosphorylation in PC12 cells. J Neurochem. 2008 Aug;106 (3) :1371-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GSK-3α; GSK-3β

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