CHIR-98023

• Description :

  CHIR-98023 is a potent, selective and reversible inhibitor of GSK3, with IC50s of 10 nM and 6.7 nM for GSK3α and GSK3β, respectively. CHIR-98023 can improve insulin action and glucose metabolism[1][2].

• CAS Number :

  [252916-76-0]

• UNSPSC :

  12352005

• Target :

  GSK-3

• Type :

  Reference compound

• Related Pathways :

  PI3K/Akt/mTOR; Stem Cell/Wnt

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/chir-98023.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=[N+](C1=CN=C(NCCNC2=NC=C(C3=NC=CN3)C(C4=CC=C(Cl)C=C4Cl)=N2)C=C1)[O-]

• Molecular Formula :

  C20H16Cl2N8O2

• Molecular Weight :

  471.30

• References & Citations :

  [1]Cline GW, et, al. Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats. Diabetes. 2002 Oct;51 (10) :2903-10.|[2]Hu M, et, al. Role of GSK-3beta activation and alpha7 nAChRs in Abeta (1-42) -induced tau phosphorylation in PC12 cells. J Neurochem. 2008 Aug;106 (3) :1371-7.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  GSK-3α; GSK-3β