CHI-KAT8i5

• Description:

  CHI-KAT8i5 is a selective and orally active KAT8 inhibitor with a KD value of 19.72 μM. CHI-KAT8i5 does not bind to other proteins in HAT family (KAT2A, KAT2B, KAT5, and KAT7) . CHI-KAT8i5 induces cancer cell apoptosis. CHI-KAT8i5 suppresses esophageal squamous cell carcinoma (ESCC) growth through targeting KAT8/c-Myc signaling pathway[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Histone Acetyltransferase

• Related Pathways:

  Apoptosis; Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Purity:

  98.00

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=S (C1=CC=C2N=C (/C=C/C3=CC=C (S (=O) (N (CC) CC) =O) C (O) =C3) SC2=C1) (N (CC) CC) =O

• Molecular Formula:

  C23H29N3O5S3

• Molecular Weight:

  523.69

• References & Citations:

  [1]Zhang D, et al. CHI-KAT8i5 suppresses ESCC tumor growth by inhibiting KAT8-mediated c-Myc stability. Cell Rep. 2025 Jan 7;44 (1) :115135.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported