CHIR-090 (Standard)

• Description:

  CHIR-090 (Standard) is the analytical standard of CHIR-090. This product is intended for research and analytical applications. CHIR-090 is a potent, slow, tight-binding inhibitor of the LpxC deacetylase. It binds to E. coli LpxC with a Ki of 4.0 nM. CHIR-090 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• UNSPSC:

  12352005

• Target:

  Antibiotic; Bacterial; Reference Standards

• Related Pathways:

  Anti-infection; Others

• Field of Research:

  Infection

• Smiles:

  O=C (N[C@@H] ([C@@H] (C) O) C (NO) =O) C (C=C1) =CC=C1C#CC2=CC=C (CN3CCOCC3) C=C2

• Molecular Formula:

  C24H27N3O5

• Molecular Weight:

  437.49

• References & Citations:

  [1]Barb AW, et al. Inhibition of lipid A biosynthesis as the primary mechanism of CHIR-090 antibiotic activity in Escherichia coli. Biochemistry. 2007 Mar 27;46 (12) :3793-802.|[2]Barb AW, et al. Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. Proc Natl Acad Sci U S A. 2007 Nov 20;104 (47) :18433-8.|[3]Tan JH, et al. In Vitro and In Vivo Efficacy of an LpxC Inhibitor, CHIR-090, Alone or Combined with Colistin against Pseudomonas aeruginosa Biofilm. Antimicrob Agents Chemother. 2017 Jun 27;61 (7) . pii: e02223-16.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  728865-23-4