CHIR-124

• Description:

  CHIR-124 is a potent and selective Chk1 inhibitor with IC50 of 0.3 nM, and also potently targets PDGFR and FLT3 with IC50s of 6.6 nM and 5.8 nM.

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  Apoptosis; Checkpoint Kinase (Chk) ; FLT3; PDGFR

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/CHIR-124.html

• Purity:

  99.05

• Solubility:

  DMSO : 7.14 mg/mL (ultrasonic)

• Smiles:

  ClC1=CC2=C(NC(C(C3=NC4=C(C=CC=C4)N3)=C2N[C@@H]5CN6CCC5CC6)=O)C=C1

• Molecular Formula:

  C23H22ClN5O

• Molecular Weight:

  419.91

• Precautions:

  H302

• References & Citations:

  [1]Tse AN, et al. CHIR-124, a novel potent inhibitor of Chk1, potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo. Clin Cancer Res, 2007, 13 (2 Pt 1), 591-602.|[2]Dai Y, et al. New insights into checkpoint kinase 1 in the DNA damage response signaling network. Clin Cancer Res, 2010, 16 (2), 376-383.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Chk1; Chk2; PDGFR

• CAS Number:

  405168-58-3