CHIR 98024

CAT: 0931-T3074-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T3074-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

556813-39-9

Target

GSK-3, S6 Kinase

Related Pathways

PI3K/Akt/mTOR signaling, MAPK, Stem Cells

Purity

0.9945

Bioactivity

CHIR 98024 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2.

Smiles

Nc1nc(NCCNc2ncc(-c3ncc[nH]3)c(n2)-c2ccc(Cl)cc2Cl)ccc1[N+]([O-])=O

Molecular Formula

C20H17Cl2N9O2

Molecular Weight

486.31

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

N2-(2-((4-(2,4-Dichlorophenyl)-5-(1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)-5-nitropyridine-2,6-diamine

CAS Number	556813-39-9
PubChem CID	9957049
IUPAC Name	6-N-[2-[[4-(2,4-dichlorophenyl)-5-(1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethyl]-3-nitropyridine-2,6-diamine
Molecular Formula	C20H17Cl2N9O2
Molecular Weight	486.3
XLogP	4.2
Topological Polar Surface Area	163
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	7
Heavy Atom Count	33
Formal Charge	0
Complexity	645

SMILES

C1=CC(=C(C=C1Cl)Cl)C2=NC(=NC=C2C3=NC=CN3)NCCNC4=NC(=C(C=C4)[N+](=O)[O-])N

InChI

InChI=1S/C20H17Cl2N9O2/c21-11-1-2-12(14(22)9-11)17-13(19-25-6-7-26-19)10-28-20(30-17)27-8-5-24-16-4-3-15(31(32)33)18(23)29-16/h1-4,6-7,9-10H,5,8H2,(H,25,26)(H3,23,24,29)(H,27,28,30)

InChIKey

NDFXSHIIGXVOKT-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 556813-39-9

CID: 9957049

Formula: C20H17Cl2N9O2

MW: 486.3

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	486.3
XLogP3	4.2
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	7
Exact Mass	485.0882262
Monoisotopic Mass	485.0882262
Topological Polar Surface Area	163 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	645
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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BUP08368-01	CHIR 98024
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B1852-25	CHIR-090
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MBS131395-01	CHIR 258
MBS5780509	CHIR-29498

CHIR 98024

Chemical Information

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