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CBI1 (formic)

CAT: 0804-HY-161242A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-161242A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CBI1 formic is a covalent BAX inhibitor. CBI1 formic selectively derivatizes BAX at C126 and inhibits BAX activation by triggering ligands or point mutagenesis. CBI1 formic blocks t-2-hex lipidation and oligomerization of BAX. CBI1 formic inhibits BAX activation induced by BH3 ligands, F116A mutagenesis or t-2-hex[1].
UNSPSC
12352005
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cbi1-formic.html
Concentration
10mM
Purity
99.54
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
BrC1=CC=C(C2=NNC(C(NCCCSSCCN)=O)=C2)C=C1.OC=O
Molecular Formula
C16H21BrN4O3S2
Molecular Weight
461.40
References & Citations
[1]Matthew W McHenry, et al. Covalent inhibition of pro-apoptotic BAX. Nat Chem Biol. 2024 Jan 17.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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