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Ivaltinostat formic

CAT: 0931-T63074-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T63074-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Others, MDM-2/p53, Apoptosis, HDAC
Related Pathways
Chromatin/Epigenetic, Apoptosis, DNA Damage/DNA Repair, Others
Bioactivity
Ivaltinostat (CG-200745) formic is an orally active pan-HDAC inhibitor with an isohydroxamic acid component that binds zinc at the bottom of the catalytic pocket. Ivaltinostat formic inhibits the deacetylation of histone H3 and tubulin, promotes p53 accumulation, induces p53-dependent transactivation, and enhances MDM2 and p21 (Waf1/Cip1) protein expression. It increases the sensitivity of Gemcitabine-resistant cells to Gemcitabine and 5-Fluorouracil (5-FU), induces apoptosis, and has antitumor effects.
Molecular Formula
C25H35N3O6
Molecular Weight
473.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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