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CBI1

CAT: 0804-HY-161242Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161242Size:1 Each
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Description
CBI1 is a covalent BAX inhibitor. CBI1 selectively derivatizes BAX at C126 and inhibits BAX activation by triggering ligands or point mutagenesis. CBI1 blocks t-2-hex lipidation and oligomerization of BAX. CBI1 inhibits BAX activation induced by BH3 ligands, F116A mutagenesis or t-2-hex[1].
UNSPSC
12352005
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cbi1.html
Solubility
10 mM in DMSO
Smiles
BrC1=CC=C(C2=NNC(C(NCCCSSCCN)=O)=C2)C=C1
Molecular Formula
C15H19BrN4OS2
Molecular Weight
415.37
References & Citations
[1]Matthew W McHenry, et al. Covalent inhibition of pro-apoptotic BAX. Nat Chem Biol. 2024 Jan 17.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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