CBI1

• Description :

  CBI1 is a covalent BAX inhibitor. CBI1 selectively derivatizes BAX at C126 and inhibits BAX activation by triggering ligands or point mutagenesis. CBI1 blocks t-2-hex lipidation and oligomerization of BAX. CBI1 inhibits BAX activation induced by BH3 ligands, F116A mutagenesis or t-2-hex[1].

• UNSPSC :

  12352005

• Target :

  Bcl-2 Family

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/cbi1.html

• Solubility :

  10 mM in DMSO

• Smiles :

  BrC1=CC=C(C2=NNC(C(NCCCSSCCN)=O)=C2)C=C1

• Molecular Formula :

  C15H19BrN4OS2

• Molecular Weight :

  415.37

• References & Citations :

  [1]Matthew W McHenry, et al. Covalent inhibition of pro-apoptotic BAX. Nat Chem Biol. 2024 Jan 17.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported