GZD856 formic

• Target:

  Apoptosis|||PDGFR|||Others|||Bcr-Abl

• Related Pathways:

  Angiogenesis|||Others|||Apoptosis|||Tyrosine Kinase/Adaptors|||Cytoskeletal Signaling

• Bioactivity:

  GZD856 formic is a potent, orally active inhibitor of PDGFR?/? and Bcr-Abl T315I, demonstrating IC50 values of 68.6 nM and 136.6 nM for PDGFR?/?, respectively, and 19.9 nM and 15.4 nM for native Bcr-Abl and the T315I mutant, respectively. This compound exhibits significant antitumor activity.

• Smiles:

  C(O)=O.C(C1=C(C(F)(F)F)C=C(NC(=O)C2=CC(C#CC3=CN4C(N=C3)=CC=N4)=C(C)C=C2)C=C1)N5CCN(C)CC5

• Molecular Formula:

  C30H29F3N6O3

• Molecular Weight:

  578.58

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2804039-78-7