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Zelavespib (formic)

CAT: 0804-HY-11038D-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-11038D-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Zelavespib formic (PU-H71 formic) is a potent Hsp90 inhibitor with an IC50 value of 51 nM for Hsp90 in MDA-MB-468 cells[1].
Product Name Alternative
PU-H71 (formic)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zelavespib-formic.html
Purity
97.39
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)NCCCN1C(SC2=C(C=C3OCOC3=C2)I)=NC4=C(N=CN=C14)N.OC=O
Molecular Formula
C19H23IN6O4S
Molecular Weight
558.39
Precautions
H302, H315, H319, H335
References & Citations
[1]Caldas-Lopes E, et al. Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models. Proc Natl Acad Sci U S A. 2009 May 19;106 (20) :8368-73.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
HSP90

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