CBI1

• Target :

  Bcl-2 Family

• Related Pathways :

  Apoptosis

• Bioactivity :

  CBI1 is a covalent BAX inhibitor. It selectively derivatizes BAX at C126 and inhibits BAX activation by triggering a ligand or through point mutations. CBI1 prevents the lipidation and oligomerization of BAX by t-2-hex. It also inhibits BAX activation induced by BH3 ligands, F116A mutation, or t-2-hex.

• Smiles :

  BrC1=CC=C(C2=NNC(C(NCCCSSCCN)=O)=C2)C=C1

• Molecular Formula :

  C15H19BrN4OS2

• Molecular Weight :

  415.37

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C