Thymidine-d2

• Description :

  Thymidine-d2 is the deuterium labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1

• CAS Number :

  [132376-92-2]

• Product Name Alternative :

  DThyd-d2; NSC 21548-d2

• UNSPSC :

  12352005

• Target :

  DNA/RNA Synthesis; Endogenous Metabolite; Isotope-Labeled Compounds; Orthopoxvirus

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1N(C=C(C(N1)=O)C)[C@]2([H])O[C@@H]([C@H](C2)O)C([2H])([2H])O

• Molecular Formula :

  C10H12D2N2O5

• Molecular Weight :

  244.24

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Chen G, et al. Cell Synchronization by Double Thymidine Block. Bio Protoc. 2018 Sep 5;8 (17) .; FIRKET H, et al. Autoradiographic visualization of synthesis of deoxyribonucleic acid in tissue culture with tritium-labelled thymidine. Nature. 1958 Jan 24;181 (4

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported