Thymidine-13C

• Description :

  Thymidine-13C is the 13C labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1]

• CAS Number :

  [478511-06-7]

• Product Name Alternative :

  DThyd-13C; NSC 21548-13C

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  DNA/RNA Synthesis; Endogenous Metabolite; Isotope-Labeled Compounds; Orthopoxvirus

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/thymidine-13c.html

• Purity :

  99.11

• Solubility :

  10 mM in DMSO

• Smiles :

  OC[C@@H]1[13C@H](C[C@H](N2C(NC(C(C)=C2)=O)=O)O1)O

• Molecular Formula :

  C9 13CH14N2O5

• Molecular Weight :

  243.22

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Chen G, et al. Cell Synchronization by Double Thymidine Block. Bio Protoc. 2018 Sep 5;8 (17) .; FIRKET H, et al. Autoradiographic visualization of synthesis of deoxyribonucleic acid in tissue culture with tritium-labelled thymidine. Nature. 1958 Jan 24;181 (4

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported