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Thymidine-d4

CAT: 0804-HY-N1150S1-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N1150S1-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Thymidine-d4 is the deuterium labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1][2][3].
CAS Number
347841-67-2
Product Name Alternative
DThyd-d4; NSC 21548-d4
UNSPSC
12352005
Target
DNA/RNA Synthesis; Endogenous Metabolite
Type
Isotope-Labeled Compounds
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Field of Research
Others
Purity
99.99
Solubility
10 mM in DMSO|DMF : ≥ 16mg/mL|DMSO : ≥ 10mg/mL
Smiles
O[C@H]1C[C@H](N2C([2H])=C(C([2H])([2H])[2H])C(NC2=O)=O)O[C@@H]1CO
Molecular Formula
C10H10D4N2O5
Molecular Weight
246.25
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]FIRKET H, et al. Autoradiographic visualization of synthesis of deoxyribonucleic acid in tissue culture with tritium-labelled thymidine. Nature. 1958 Jan 24;181 (4604) :274-5.FIRKET H, et al. Autoradiographic visualization of synthesis of deoxyribonucleic acid in tissue culture with tritium-labelled thymidine. Nature. 1958 Jan 24;181 (4604) :274-5.|[3]Izeradjene K, et al. Inhibition of thymidine synthesis by folate analogues induces a Fas-Fas ligand-independentdeletion of superantigen-reactive peripheral T cells. Int Immunol. 2001 Jan;13 (1) :85-93.|[4]Chen G, et al. Cell Synchronization by Double Thymidine Block. Bio Protoc. 2018 Sep 5;8 (17) .
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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