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Thymidine-d14

CAT: 0804-HY-N1150S10Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N1150S10Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Thymidine-d14 (DThyd-d14; NSC 21548-d14) is deuterium labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication.
CAS Number
1134181-96-6
Product Name Alternative
DThyd-d14; NSC 21548-d14
UNSPSC
12352005
Target
DNA/RNA Synthesis; Endogenous Metabolite; Isotope-Labeled Compounds; Orthopoxvirus
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
O=C(C(C([2H])([2H])[2H])=C1[2H])N([2H])C(N1[C@@]2([2H])C([2H])([2H])[C@@](O[2H])([2H])[C@](C([2H])([2H])O[2H])([2H])O2)=O
Molecular Formula
C10D14N2O5
Molecular Weight
256.31
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Chen G, et al. Cell Synchronization by Double Thymidine Block. Bio Protoc. 2018 Sep 5;8 (17) .|[3]FIRKET H, et al. Autoradiographic visualization of synthesis of deoxyribonucleic acid in tissue culture with tritium-labelled thymidine. Nature. 1958 Jan 24;181 (4604) :274-5.FIRKET H, et al. Autoradiographic visualization of synthesis of deoxyribonucleic acid in tissue culture with tritium-labelled thymidine. Nature. 1958 Jan 24;181 (4604) :274-5.|[4]Izeradjene K, et al. Inhibition of thymidine synthesis by folate analogues induces a Fas-Fas ligand-independentdeletion of superantigen-reactive peripheral T cells. Int Immunol. 2001 Jan;13 (1) :85-93.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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