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PROTAC CDK6 Degrader 1

CAT: 0013-GTR19275850-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19275850-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTACCDK6 Degrader 1 (compound 48a) is an effective and selective PROTAC CDK6 degrader with a DC50 of 0.037 μM. It shows selectivity for CDK4 with a DC50 greater than 10 μM. This compound induces G0/G1 phase cell cycle arrest and apoptosis by inhibiting the downstream signaling pathways of CDK6. In the MOLM-14 xenograft mouse model, PROTACCDK6 Degrader 1 reduces tumor burden and CDK6 levels. It is a valuable tool for researching CDK6-driven cancers, such as acute myeloid leukemia (AML) .
Storage Conditions
-20°C
Notes
For research use only.

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