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PROTAC CDK9 degrader-2

CAT: 0013-GTR19225744-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19225744-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTAC CDK9 degrader-2 (compounds 11c) is a potent and selective CDK9-targeting PROTAC with an IC50 of 17 μM in MCF-7 cells. It is constructed by linking a CDK9 ligand to the natural product Wogonin, which binds the E3 ligase CRBN. This molecule is a useful chemical tool for studying CDK9 biology and targeted protein degradation in cancer research models.
CAS Number
2435721-30-3
Field of Research
Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery
Smiles
O=C (C=C (C1=CC=CC=C1) O2) C3=C2C (OCC4=CN (CCCCCCCC (NC5=C (C (N (C6C (NC (CC6) =O) =O) C7=O) =O) C7=CC=C5) =O) N=N4) =C (O) C=C3O
Molecular Formula
C39H36N6O10
Molecular Weight
748.74
Storage Conditions
-20°C
Notes
For research use only.

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