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PROTAC CDK4/6 degrader 1

CAT: 0013-GTR19236309-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19236309-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Compound 7f (PROTAC CDK4/6 degrader 1) is a potent dual degrader of CDK4 (DC50=10.5 nM) and CDK6 (DC50=2.5 nM) . It induces G1 phase arrest and apoptosis, inhibiting proliferation in Jurkat cells (IC50=0.18 μM), and is a valuable tool for cancer research in vitro.
CAS Number
3025082-14-5
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Smiles
O=C1C=NC=2C=NC (=NC2N1C3CCCC3) NC4=CC=C (C=C4) N5CCN (CC5) CCCCC (=O) NCCNC6=CC=CC=7C (=O) N (C (=O) C67) C8C (=O) NC (=O) CC8
Molecular Formula
C41H47N11O6
Molecular Weight
789.88
Storage Conditions
-20°C
Notes
For research use only.

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