PH-002

CAT: 0804-HY-112798-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-112798-01Size:5 mg
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Description
PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells that could rescue impairments of mitochondrial motility and neurite outgrowth.
CAS Number
[1311174-68-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apolipoprotein
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/PH-002.html
Concentration
10mM
Purity
98.78
Solubility
DMSO : ≥ 75 mg/mL
Smiles
O=C(N1CCN(CC2=CC=C(NC(CC3=NN(C)C(C4=C3C=CC=C4)=O)=O)C=C2)CC1)OC(C)(C)C
Molecular Formula
C27H33N5O4
Molecular Weight
491.58
Precautions
H302, H315, H319, H335
References & Citations
[1]Brodbeck J, et al. Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors. J Biol Chem. 2011 May 13;286 (19) :17217-26.|[2]Chen HK, et al. Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons. J Biol Chem. 2012 Feb 17;287 (8) :5253-66.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ApoE

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