PD-1/PD-L1-IN-43

PD-1/PD-L1-IN-43

• UNSPSC Description: PD-1/PD-L1-IN-43 (compound Z13) is a small-molecule inhibitors targeting the PD-1/PD-L1 interaction. PD-1/PD-L1-IN-43 exhibites potent in vivo antitumor efficacy against B16-F10 melanoma. PD-1/PD-L1-IN-43 inhibits tumor growth by blocking the interaction between PD-1 and PD-L1. PD-1/PD-L1-IN-43 can be used in anti-tumor studies[1].
• Target Antigen: PD-1/PD-L1
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pd-1-pd-l1-in-43.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(N1N=CC2=C1C=CC=C2C3=CC=C4OCCOC4=C3)C5=CC=C(C=C5)CN6CC[C@H](C6)O
• Molecular Weight: 455.51
• References & Citations: [1]Xu C, et al. Discovery of 4-phenyl-1H-indazole derivatives as novel small-molecule inhibitors targeting the PD-1/PD-L1 interaction[J]. Bioorganic Chemistry, 2024: 107376.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported