NCT-505

• Description :

  NCT-505 is a potent and selective aldehyde dehydrogenase (ALDH1A1) inhibitor, with an IC50 of 7 nM, and weakly inhibits hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 (IC50s, >57, 22.8, 20.1, >57 μM) .

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319

• Target :

  Aldehyde Dehydrogenase (ALDH)

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/NCT-505.html

• Purity :

  99.37

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  N#CC1(C2=CC=CC=C2)CCN(C3=C(C(N4CCN(S(=O)(C)=O)CC4)=O)C=NC5=CC=C(F)C=C35)CC1

• Molecular Formula :

  C27H28FN5O3S

• Molecular Weight :

  521.61

• Precautions :

  H302, H315, H319

• References & Citations :

  [1]Yang SM, et al. Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity. J Med Chem. 2018 Jun 14;61 (11) :4883-4903.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  ALDH1

• CAS Number :

  [2231079-74-4]