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NCT-505

CAT: 0804-HY-112277-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-112277-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NCT-505 is a potent and selective aldehyde dehydrogenase (ALDH1A1) inhibitor, with an IC50 of 7 nM, and weakly inhibits hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 (IC50s, >57, 22.8, 20.1, >57 μM) .
CAS Number
[2231079-74-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Aldehyde Dehydrogenase (ALDH)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NCT-505.html
Purity
99.37
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CC1(C2=CC=CC=C2)CCN(C3=C(C(N4CCN(S(=O)(C)=O)CC4)=O)C=NC5=CC=C(F)C=C35)CC1
Molecular Formula
C27H28FN5O3S
Molecular Weight
521.61
Precautions
H302, H315, H319
References & Citations
[1]Yang SM, et al. Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity. J Med Chem. 2018 Jun 14;61 (11) :4883-4903.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ALDH1

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Alternative Products

CatalogName
M13578-01NCT-505
A19669-1NCT-505 1mg
A19669-10NCT-505 10mg
A19669-5NCT-505 5mg
A19669-25NCT-505 25mg
A19669-100NCT-505 100mg
A19669-200NCT-505 200mg
A19669-50NCT-505 50mg
MBS3603576-01NCT-505 free base
A19669-10mM-DNCT-505 10mM * 1mL in DMSO

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