NCT-502
CAT:
804-HY-117240-05
Size:
100 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
NCT-502
- CAS Number: 1542213-00-2
- UNSPSC Description: NCT-502 is a human phosphoglycerate dehydrogenase (PHGDH) inhibitor, cytotoxic to PHGDH-dependent cancer cells, and reduces glucose-derived serine production, with an IC50 of 3.7 μM against PHGDH[1].
- Target Antigen: Phosphoglycerate Dehydrogenase (PHGDH)
- Type: Reference compound
- Related Pathways: Metabolic Enzyme/Protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/nct-502.html
- Purity: 99.72
- Solubility: DMSO : 130 mg/mL (ultrasonic)
- Smiles: S=C(NC1=NC(C)=CC(C)=C1)N2CCN(CC2)C3=NC=C(C=C3)C(F)(F)F
- Molecular Weight: 395.45
- References & Citations: [1]Rohde JM, et al. Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors. Bioorg Med Chem. 2018 May 1;26(8):1727-1739.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported