NCT-502

• Description:

  NCT-502 is a human phosphoglycerate dehydrogenase (PHGDH) inhibitor, cytotoxic to PHGDH-dependent cancer cells, and reduces glucose-derived serine production, with an IC50 of 3.7 μM against PHGDH[1].

• Product Name Alternative:

  NSC51355

• UNSPSC:

  12352005

• Target:

  Phosphoglycerate Dehydrogenase (PHGDH)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/nct-502.html

• Concentration:

  10mM

• Purity:

  98.59

• Solubility:

  DMSO : 130 mg/mL (ultrasonic)

• Smiles:

  S=C(NC1=NC(C)=CC(C)=C1)N2CCN(CC2)C3=NC=C(C=C3)C(F)(F)F

• Molecular Formula:

  C18H20F3N5S

• Molecular Weight:

  395.45

• References & Citations:

  [1]Rohde JM, et al. Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors. Bioorg Med Chem. 2018 May 1;26 (8) :1727-1739.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1542213-00-2]