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Antitumor agent-174

CAT: 0013-GTR19262929-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19262929-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Antitumor agent-174 (Compound 10) directly binds to the N-terminal site of Hsp90, promoting the degradation of β-catenin and thereby inhibiting Wnt/β-catenin signaling. This compound effectively suppresses the proliferation of colorectal cancer (CRC) cells, induces S and G2/M phase arrest, and prevents cell colony formation. It downregulates proteins such as CDK1, Cyclin D1, c-Myc, Cyclin B1, and Cyclin A2, while upregulating P21. Antitumor agent-174 exhibits significant antitumor activity against CRC, offering excellent pharmacokinetics and low toxicity.
Field of Research
Cell Biology, Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology
Molecular Formula
C20H18Cl2N2
Storage Conditions
-20°C
Notes
For research use only.

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