NF-κB-IN-16

CAT: 0013-GTR19262392-01Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19262392-01Size:50 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

NF-κB-IN-16 (compound 9) is a complex of an NF-κB inhibitor and Cisplatin (Pt (IV) complex) with potent and low-toxicity antitumor activity. It can cause DNA damage, induce mitochondrial dysfunction, generate reactive oxygen species, and trigger apoptosis via mitochondrial pathways and endoplasmic reticulum stress. NF-κB-IN-16 effectively inhibits the NF-κB/MAPK signaling pathway and disrupts PI3K/AKT signal transduction. Additionally, it demonstrates excellent in vivo antitumor efficacy and low toxicity in A549 or A549/CDDP xenograft models.

Field of Research

Cell Biology, Signal Transduction

Molecular Formula

C26H35Cl3N2O10Pt

Storage Conditions

-20°C

Notes

For research use only.

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NF-κB-IN-16

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