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PI4K-IN-1

CAT: 0804-HY-106012-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-106012-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PI4K-IN-1 (compound 44) is a potent PI4KIII inhibitor, with pIC50 values of 9.0 and 6.6 for PI4KIIIα and PI4KIIIβ, respectively. PI4K-IN-1 also inhibits PI3Kα/β/γ/δ, with pIC50 values of 4.0/[1].
CAS Number
1800017-49-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PI3K; PI4K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pi4k-in-1.html
Purity
98.61
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
OC([C@@H](CC1)CC[C@H]1CNC2=NC3=CC=C(C4=CC(N(CC5CC5)C=C4)=O)C=C3S2)=O
Molecular Formula
C24H27N3O3S
Molecular Weight
437.55
Precautions
H302, H315, H319, H335
References & Citations
[1]Raubo P, et al. Discovery of potent, selective small molecule inhibitors of α-subtype of type III phosphatidylinositol-4-kinase (PI4KIIIα) . Bioorg Med Chem Lett. 2015 Aug 15;25 (16) :3189-93.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ; PI4KIIIα; PI4KIIIβ

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