PI4K-IN-1

• UNSPSC Description:

  PI4K-IN-1 (compound 44) is a potent PI4KIII inhibitor, with pIC50 values of 9.0 and 6.6 for PI4KIIIα and PI4KIIIβ, respectively. PI4K-IN-1 also inhibits PI3Kα/β/γ/δ, with pIC50 values of 4.0/[1].

• Target Antigen:

  PI3K; PI4K

• Type:

  Reference compound

• Related Pathways:

  PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pi4k-in-1.html

• Purity:

  98.61

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  OC([C@@H](CC1)CC[C@H]1CNC2=NC3=CC=C(C4=CC(N(CC5CC5)C=C4)=O)C=C3S2)=O

• Molecular Weight:

  437.55

• References & Citations:

  [1]Raubo P, et al. Discovery of potent, selective small molecule inhibitors of α-subtype of type III phosphatidylinositol-4-kinase (PI4KIIIα). Bioorg Med Chem Lett. 2015 Aug 15;25(16):3189-93.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1800017-49-5