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PI4Kβ/PKG-IN-2

CAT: 0804-HY-174134Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174134Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PI4Kβ/PKG-IN-2 (Compound 20) is an orally active dual inhibitor of Plasmodium phosphatidylinositol 4-kinase beta (PI4Kβ) and cGMP-dependent protein kinase (PKG) . PI4Kβ/PKG-IN-2 has potent inhibitory effects on Plasmodium. PI4Kβ/PKG-IN-2 is promising for research of malaria[1].
CAS Number
3099010-20-2
UNSPSC
12352005
Target
Parasite; PI4K; PKG
Related Pathways
Anti-infection; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Infection
Smiles
NC1=NC2=CC(C3=NN(CC4=CC=C(Cl)C(Cl)=C4)C5=NC=NC(N)=C53)=CC=C2O1
Molecular Formula
C19H13Cl2N7O
Molecular Weight
426.26
References & Citations
[1]Gachuhi S, et al. Medicinal Chemistry Progression of Sapanisertib, the Anticancer and Dual Plasmodium Phosphatidylinositol 4-Kinase Beta and cGMP-Dependent Protein Kinase Inhibitor, for Malaria. J Med Chem. 2025 Jun 12;68 (11) :10757-10770.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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