PI4Kβ/PKG-IN-2

• Description:

  PI4Kβ/PKG-IN-2 (Compound 20) is an orally active dual inhibitor of Plasmodium phosphatidylinositol 4-kinase beta (PI4Kβ) and cGMP-dependent protein kinase (PKG) . PI4Kβ/PKG-IN-2 has potent inhibitory effects on Plasmodium. PI4Kβ/PKG-IN-2 is promising for research of malaria[1].

• UNSPSC:

  12352005

• Target:

  Parasite; PI4K; PKG

• Related Pathways:

  Anti-infection; PI3K/Akt/mTOR; Stem Cell/Wnt

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Smiles:

  NC1=NC2=CC(C3=NN(CC4=CC=C(Cl)C(Cl)=C4)C5=NC=NC(N)=C53)=CC=C2O1

• Molecular Formula:

  C19H13Cl2N7O

• Molecular Weight:

  426.26

• References & Citations:

  [1]Gachuhi S, et al. Medicinal Chemistry Progression of Sapanisertib, the Anticancer and Dual Plasmodium Phosphatidylinositol 4-Kinase Beta and cGMP-Dependent Protein Kinase Inhibitor, for Malaria. J Med Chem. 2025 Jun 12;68 (11) :10757-10770.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [3099010-20-2]