PI4Kβ/PKG-IN-1

• Description:

  PI4Kβ/PKG-IN-1 (Compound 19) is an orally active dual inhibitor targeting Plasmodium phosphatidylinositol 4-kinase beta (PI4Kβ) and cGMP-dependent protein kinase (PKG) . PI4Kβ/PKG-IN-1 exhibits potent antiplasmodial activity. PI4Kβ/PKG-IN-1 is promising for research of malaria[1].

• UNSPSC:

  12352005

• Target:

  Parasite; PI4K; PKG

• Related Pathways:

  Anti-infection; PI3K/Akt/mTOR; Stem Cell/Wnt

• Field of Research:

  Infection

• Smiles:

  NC1=NC2=CC (C3=NN (CC4=CC=C (Cl) C (F) =C4) C5=NC=NC (N) =C53) =CC=C2O1

• Molecular Formula:

  C19H13ClFN7O

• Molecular Weight:

  409.80

• References & Citations:

  [1]Gachuhi S, et al. Medicinal Chemistry Progression of Sapanisertib, the Anticancer and Dual Plasmodium Phosphatidylinositol 4-Kinase Beta and cGMP-Dependent Protein Kinase Inhibitor, for Malaria. J Med Chem. 2025 Jun 12;68 (11) :10757-10770.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported