PI4K-IN-3

CAT: 0804-HY-178775Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-178775Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PI4K-IN-3 (Compound 27) is an orally active PI4K inhibitor with an IC50 of 1.9 nM for Plasmodium vivax PI4K. PI4K-IN-3 has no hERG channel inhibition and mammalian cytotoxicity. PI4K-IN-3 has significant selectivity against the human MINK1 and MAP4K4 kinases but with low selectivity against human PI3Kα and PI4Kβ. PI4K-IN-3 has potent antimalarial activity and significantly reduces parasitaemia in NSG mice mouse models of Plasmodium falciparum malaria[1].
UNSPSC
12352005
Target
MAP4K; Parasite; PI3K; PI4K
Related Pathways
Anti-infection; MAPK/ERK Pathway; PI3K/Akt/mTOR
Field of Research
Infection
Smiles
OC(C)(C1=CC=C(C2=C3C(C=CC(C4=CC(CC(NC)=O)=CC=C4)=N3)=NC=C2)C=N1)C
Molecular Formula
C25H24N4O2
Molecular Weight
412.48
References & Citations
[1]Dziwornu GA, et al. Optimization of 2,8-Diaryl-1,5-naphthyridines as Plasmodium falciparum Phosphatidylinositol 4-Kinase Inhibitors with Improved ADME Profiles and In Vivo Efficacy. J Med Chem. 2025 Oct 23;68 (20) :21878-21891.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAP4K4/HGK; MAP4K6/MINK1; PI3Kα; PI4K; Plasmodium

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