PI4K-IN-3

• Description:

  PI4K-IN-3 (Compound 27) is an orally active PI4K inhibitor with an IC50 of 1.9 nM for Plasmodium vivax PI4K. PI4K-IN-3 has no hERG channel inhibition and mammalian cytotoxicity. PI4K-IN-3 has significant selectivity against the human MINK1 and MAP4K4 kinases but with low selectivity against human PI3Kα and PI4Kβ. PI4K-IN-3 has potent antimalarial activity and significantly reduces parasitaemia in NSG mice mouse models of Plasmodium falciparum malaria[1].

• UNSPSC:

  12352005

• Target:

  MAP4K; Parasite; PI3K; PI4K

• Related Pathways:

  Anti-infection; MAPK/ERK Pathway; PI3K/Akt/mTOR

• Field of Research:

  Infection

• Smiles:

  OC (C) (C1=CC=C (C2=C3C (C=CC (C4=CC (CC (NC) =O) =CC=C4) =N3) =NC=C2) C=N1) C

• Molecular Formula:

  C25H24N4O2

• Molecular Weight:

  412.48

• References & Citations:

  [1]Dziwornu GA, et al. Optimization of 2,8-Diaryl-1,5-naphthyridines as Plasmodium falciparum Phosphatidylinositol 4-Kinase Inhibitors with Improved ADME Profiles and In Vivo Efficacy. J Med Chem. 2025 Oct 23;68 (20) :21878-21891.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  MAP4K4/HGK; MAP4K6/MINK1; PI3Kα; PI4K; Plasmodium