Products for Research Use Only

PRMT5/EGFR-IN-1

CAT: 0013-GTR19262123-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19262123-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PRMT5/EGFR-IN-1 (Compound 10p) is an orally active dual inhibitor targeting PRMT5 and EGFR, with IC50 values of 15.47 μM and 19.31 μM, respectively. It demonstrates antiproliferative activity against the A549, MCF7, HeLa, and MDA-MB-231 cell lines. This compound also exhibits favorable pharmacokinetic (PK) and pharmacodynamic (PD) properties in vivo and significantly inhibits the growth of MCF7 orthotopic xenograft tumors.
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Epigenetics & Chromatin; Cell Biology, Signal Transduction
Molecular Formula
C27H22F6N2O2
Storage Conditions
-20°C
Notes
For research use only.