EGFR-IN-1

CAT: 0931-T11157-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T11157-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1625677-63-5

Target

EGFR

Related Pathways

Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors

Bioactivity

EGFR-IN-1, an orally active and irreversible selective inhibitor targeting L858R/T790M mutant EGFR, exhibits strong antiproliferative and antitumor activity, particularly against H1975 cells and first line mutant HCC827 cells. This compound potently inhibits Gefitinib-resistant EGFR L858R/T790M mutations with a 100-fold selectivity over the wild-type EGFR.

Smiles

O=C1N(C=2C(=CN=C(NC3=C(OC)C=C(OCCN(C)C)C=C3)N2)C(C)=C1)C4=CC(NC(C=C)=O)=CC=C4

Molecular Formula

C28H30N6O4

Molecular Weight

514.58

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Catalog	Name
sc-80543	EGFR (EGFR.1)
HY-19617	EGFR-IN-1
MBS3030021-01	anti-Human EGFR antibody (EGFR.1)
HY-168492-01	TrxR/EGFR-IN-1
HY-19617A-01	EGFR-IN-1 (hydrochloride)
HY-152019	EGFR/C797S-IN-1
HY-78869-01	Mutated EGFR-IN-1
HY-161136	EGFR/STAT3-IN-1
HY-168073	EGFR/VEGFR2-IN-1
HY-163726-01	GLUT1/EGFR-IN-1

EGFR-IN-1

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