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MXC-017

CAT: 0013-GTR19263387-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263387-01Size:50 mg
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Description
MXC-017 is an apoptosis inducer capable of crossing the blood-brain barrier, specifically targeting glioma stem cells (GSCs) . It effectively prevents the formation of radiation-induced GSCs while promoting G0/G1 cell cycle arrest and apoptosis. With minimal off-target effects, MXC-017 exhibits no significant cytotoxicity even at concentrations up to 10 μM. Additionally, it significantly extends the median survival in patient-derived orthotopic xenograft (PDOX) glioblastoma (GBM) mouse models when used in conjunction with radiation therapy.
CAS Number
3037024-97-5
Field of Research
Cell Biology
Smiles
O=C (NCC1=CC=C (C=C1) S (=O) (=O) N2CCCCC2) N3C=CC=4C=CC=CC43
Molecular Formula
C21H23N3O3S
Molecular Weight
397.49
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-[(4-piperidin-1-ylsulfonylphenyl)methyl]indole-1-carboxamide
CAS Number3037024-97-5
PubChem CID171536167
IUPAC NameN-[(4-piperidin-1-ylsulfonylphenyl)methyl]indole-1-carboxamide
Molecular FormulaC21H23N3O3S
Molecular Weight397.5
XLogP3.2
Topological Polar Surface Area79.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count28
Formal Charge0
Complexity634
SMILES
C1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)CNC(=O)N3C=CC4=CC=CC=C43
InChI
InChI=1S/C21H23N3O3S/c25-21(24-15-12-18-6-2-3-7-20(18)24)22-16-17-8-10-19(11-9-17)28(26,27)23-13-4-1-5-14-23/h2-3,6-12,15H,1,4-5,13-14,16H2,(H,22,25)
InChIKey
VPFAUCOTIMKXOD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-[(4-piperidin-1-ylsulfonylphenyl)methyl]indole-1-carboxamide
CAS: 3037024-97-5
CID: 171536167
Formula: C21H23N3O3S
MW: 397.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight397.5
XLogP33.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass397.14601278
Monoisotopic Mass397.14601278
Topological Polar Surface Area79.8 Ų
Heavy Atom Count28
Formal Charge0
Complexity634
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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