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MTX-216

CAT: 0013-GTR19258650-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19258650-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MTX-216 is an ATP-competitive inhibitor targeting both PI3K and EGFR. It simultaneously inhibits Ki-67 and ribosomal S6 phosphorylation, inducing apoptosis in NF1LOF cells. Additionally, MTX-216 suppresses SYK kinase activity with an IC50 of 281 nM. This compound is applicable for melanoma research.
CAS Number
1952236-19-9
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Smiles
N#CC=1C=NC2=CC=C (C=C2C1NC3=CC=C (F) C (Cl) =C3) C=4C=NC (Cl) =C (C4) NS (=O) (=O) C
Molecular Formula
C22H14Cl2FN5O2S
Molecular Weight
502.348
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-(2-chloro-5-(4-((3-chloro-4-fluorophenyl)amino)-3-cyanoquinolin-6-yl)pyridin-3-yl)methanesulfonamide
CAS Number1952236-19-9
PubChem CID121416263
IUPAC NameN-[2-chloro-5-[4-(3-chloro-4-fluoroanilino)-3-cyanoquinolin-6-yl]-3-pyridinyl]methanesulfonamide
Molecular FormulaC22H14Cl2FN5O2S
Molecular Weight502.3
XLogP5.2
Topological Polar Surface Area116
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Heavy Atom Count33
Formal Charge0
Complexity836
SMILES
CS(=O)(=O)NC1=C(N=CC(=C1)C2=CC3=C(C(=CN=C3C=C2)C#N)NC4=CC(=C(C=C4)F)Cl)Cl
InChI
InChI=1S/C22H14Cl2FN5O2S/c1-33(31,32)30-20-7-13(10-28-22(20)24)12-2-5-19-16(6-12)21(14(9-26)11-27-19)29-15-3-4-18(25)17(23)8-15/h2-8,10-11,30H,1H3,(H,27,29)
InChIKey
WEVXFHBMHZDTAQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(2-chloro-5-(4-((3-chloro-4-fluorophenyl)amino)-3-cyanoquinolin-6-yl)pyridin-3-yl)methanesulfonamide
CAS: 1952236-19-9
CID: 121416263
Formula: C22H14Cl2FN5O2S
MW: 502.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight502.3
XLogP35.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Exact Mass501.0229294
Monoisotopic Mass501.0229294
Topological Polar Surface Area116 Ų
Heavy Atom Count33
Formal Charge0
Complexity836
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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