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DMT1 blocker 1

CAT: 0804-HY-126301-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-126301-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DMT1 blocker 1 is an orally active blocker of divalent metal transporter 1 (DMT1) with an IC50 of 0.64 μM. DMT1 blocker 1 inhibits intestinal cell absorption of non-heme iron, thereby alleviating iron overload by blocking the DMT1 transporter. DMT1 blocker 1 demonstrates significant efficacy in rodent models of acute iron hyperabsorption. DMT1 blocker 1 is useful for studying iron overload disorders such as hereditary hemochromatosis and thalassemia[1].
CAS Number
1354790-56-9
UNSPSC
12352005
Target
Ferroportin
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/dmt1-blocker-1.html
Purity
99.79
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC1=C(C(NC2=CC=CC=C2)=O)C(C)=NN1C3=NC=CC=C3
Molecular Formula
C16H14N4O2
Molecular Weight
294.31
References & Citations
[1]Cadieux JA, et al. Synthesis and biological evaluation of substituted pyrazoles as blockers of divalent metal transporter 1 (DMT1) . Bioorg Med Chem Lett. 2012 Jan 1;22 (1) :90-5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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