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PROTAC K-Ras Degrader-2

CAT: 0013-GTR19249744-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19249744-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTAC K-Ras degrader-2 is a pan-KRAS mutant degrader with potent activity, exhibiting degradation (DC50 ≤200 nM) and growth inhibition (IC50 ≤20 nM) in KRAS-mutant cancer cell models. This tool compound is valuable for in vitro and in vivo research targeting oncogenic KRAS signaling in cancers.
CAS Number
3043670-74-9
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Smiles
C (C1 (COC=2N=C (C3=C (N2) C (F) =C (N=C3) C=4C5=C (C=C (O) C4) C=CC (F) =C5CC) N6C[C@] (C) (O) CCC6) CC1) N7CCC (CN8CCN (CC8) C9=CC (F) =C (C (F) =C9) C%10C (=O) NC (=O) CC%10) (C) CC7
Molecular Formula
C52H60F4N8O5
Molecular Weight
953.077
Storage Conditions
-20°C
Notes
For research use only.

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