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2-Hydroxychalcone B

CAT: 0013-GTR19243442-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19243442-01Size:500 mg
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Description
2'-Hydroxychalcone is a drug synthesis intermediate for the synthesis of flavonoids. 2'-Hydroxychalcone loaded in nanoemulsion showed fungicidal activity against Coccidioides parapsilosis in Danio rerio model.2'-Hydroxychalcone induced cytotoxicity through oxidative stress in lipid-loaded Hepg2 cells.2'-Hydroxychalcone inhibited the induction of ICAM-1, VCAM-α, tumor necrosis factor-α, and tumor necrosis factor-alpha as determined by reverse transcription-polymerase chain reaction determined by tumor necrosis factor-alpha induces steady-state transcript levels of ICAM-1, VCAM-1, and E-selectin, and therefore may interfere with the transcription of their genes.
CAS Number
1214-47-7
Purity
>98% (HPLC)
Smiles
Oc1ccccc1C (=O) \C=C\c1ccccc1
Molecular Formula
C15H12O2
Molecular Weight
224.25
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

2'-Hydroxychalcone

2'-hydroxychalcone is a member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 2'. It has a role as an anti-inflammatory agent. It is a member of chalcones and a member of phenols. It is functionally related to a trans-chalcone.

CAS Number1214-47-7
PubChem CID638276
IUPAC Name(E)-1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one
Molecular FormulaC15H12O2
Molecular Weight224.25
XLogP3.9
Topological Polar Surface Area37.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Heavy Atom Count17
Formal Charge0
Complexity277
SMILES
C1=CC=C(C=C1)/C=C/C(=O)C2=CC=CC=C2O
InChI
InChI=1S/C15H12O2/c16-14-9-5-4-8-13(14)15(17)11-10-12-6-2-1-3-7-12/h1-11,16H/b11-10+
InChIKey
AETKQQBRKSELEL-ZHACJKMWSA-N
Chemical Structure
2D Structure
2D structure of 2'-Hydroxychalcone
CAS: 1214-47-7
CID: 638276
Formula: C15H12O2
MW: 224.25
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight224.25
XLogP33.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Exact Mass224.083729621
Monoisotopic Mass224.083729621
Topological Polar Surface Area37.3 Ų
Heavy Atom Count17
Formal Charge0
Complexity277
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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