2′-Hydroxychalcone

• Description :

  2′-Hydroxychalcone is a hydroxyl derivative of chalcones with anticancer activities. 2'-Hydroxychalcone inhibits NF-κB pathway and induces autophagy and apoptosis in breast cancer cells[1]. 2′-Hydroxychalcone shows a better antifungal activity against the complex Paracoccidioides spp[2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Apoptosis; Autophagy; Fungal; NF-κB

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Apoptosis; Autophagy; NF-κB

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Infection

• Assay Protocol :

  https://www.medchemexpress.com/2-hydroxychalcone-1.html

• Purity :

  97.45

• Solubility :

  DMSO : 200 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=C(O)C=CC=C1)/C=C/C2=CC=CC=C2

• Molecular Formula :

  C15H12O2

• Molecular Weight :

  224.26

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Kaila P Medina-Alarcón, et al. Antifungal activity of 2'-hydroxychalcone loaded in nanoemulsion against Paracoccidioides spp. Future Microbiol. 2020 Jan:15:21-33. |[2]Xiao Wang, et al. 2'-Hydroxychalcone Induces Autophagy and Apoptosis in Breast Cancer Cells via the Inhibition of the NF-κB Signaling Pathway: In Vitro and In Vivo Studies. Nutrients. 2024 Feb 13;16 (4) :514.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1214-47-7]