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2′-Hydroxychalcone

CAT: 0804-HY-W012349-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-W012349-01Size:100 mg
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Description
2′-Hydroxychalcone is a hydroxyl derivative of chalcones with anticancer activities. 2'-Hydroxychalcone inhibits NF-κB pathway and induces autophagy and apoptosis in breast cancer cells[1]. 2′-Hydroxychalcone shows a better antifungal activity against the complex Paracoccidioides spp[2].
CAS Number
[1214-47-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; Fungal; NF-κB
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Autophagy; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/2-hydroxychalcone-1.html
Purity
97.45
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C(C1=C(O)C=CC=C1)/C=C/C2=CC=CC=C2
Molecular Formula
C15H12O2
Molecular Weight
224.26
Precautions
H302, H315, H319, H335
References & Citations
[1]Kaila P Medina-Alarcón, et al. Antifungal activity of 2'-hydroxychalcone loaded in nanoemulsion against Paracoccidioides spp. Future Microbiol. 2020 Jan:15:21-33. |[2]Xiao Wang, et al. 2'-Hydroxychalcone Induces Autophagy and Apoptosis in Breast Cancer Cells via the Inhibition of the NF-κB Signaling Pathway: In Vitro and In Vivo Studies. Nutrients. 2024 Feb 13;16 (4) :514.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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