2′-Hydroxychalcone

• UNSPSC Description:

  2′-Hydroxychalcone is a hydroxyl derivative of chalcones with anticancer activities. 2'-Hydroxychalcone inhibits NF-κB pathway and induces autophagy and apoptosis in breast cancer cells[1]. 2′-Hydroxychalcone shows a better antifungal activity against the complex Paracoccidioides spp[2].

• Target Antigen:

  Apoptosis; Autophagy; Fungal; NF-κB

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Apoptosis;Autophagy;NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/2-hydroxychalcone-1.html

• Purity:

  96.76

• Solubility:

  DMSO : 200 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=C(O)C=CC=C1)/C=C/C2=CC=CC=C2

• Molecular Weight:

  224.259

• References & Citations:

  [1]Kaila P Medina-Alarcón, et al. Antifungal activity of 2'-hydroxychalcone loaded in nanoemulsion against Paracoccidioides spp. Future Microbiol. 2020 Jan:15:21-33. |[2]Xiao Wang, et al. 2'-Hydroxychalcone Induces Autophagy and Apoptosis in Breast Cancer Cells via the Inhibition of the NF-κB Signaling Pathway: In Vitro and In Vivo Studies. Nutrients. 2024 Feb 13;16(4):514.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1214-47-7