2-Hydroxychalcone

• Description:

  2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB[1][2][3].

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319

• Target:

  Apoptosis; Bcl-2 Family; NF-κB; Parasite

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Apoptosis; NF-κB

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Cancer; Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/2-hydroxychalcone.html

• Concentration:

  10mM

• Purity:

  98.13

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O=C (C1=CC=CC=C1) /C=C/C2=CC=CC=C2O

• Molecular Formula:

  C15H12O2

• Molecular Weight:

  224.25

• Precautions:

  H315, H319

• References & Citations:

  [1]Sun Young Kim, et al. 2-Hydroxychalcone and Xanthohumol Inhibit Invasion of Triple Negative Breast Cancer Cells. Chem Biol Interact. 2013 May 25;203 (3) :565-72.|[2]B Madan, et al. 2'-hydroxychalcone Inhibits Nuclear factor-kappaB and Blocks Tumor Necrosis Factor-Alpha- And Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol. 2000 Sep;58 (3) :526-34.|[3]BABITA MADAN, et al. 2-Hydroxychalcone Inhibits Nuclear Factor-kB and Blocks Tumor Necrosis Factor-a- and Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol 58:526–534, 2000.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  644-78-0