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4-Hydroxychalcone

CAT: 0013-GTR19171121-01Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19171121-01Size:1 ml x 10 mM (in DMSO)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This small molecule, 4-Hydroxychalcone, has been shown to mitigate hyperaldosteronism, inflammation, and renal injury in cryptochrome-deficient murine models. It serves as a useful research tool for studying chronobiology, steroid hormone pathways, and cardiorenal pathophysiology in both in vivo and in vitro experimental systems.
CAS Number
20426-12-4
Product Name Alternative
4 Hydroxychalcone, 4Hydroxychalcone, 4-Hydroxychalcone, inhibit, Nuclear factor-κB, Nuclear factor-kappaB, NFkB, NF-kB, NFκB, NF-κB, P-Cinnamoylphenol, Inhibitor
Field of Research
Signal Transduction
Purity
99.75% (May vary between batches)
Solubility
DMSO:45 mg/mL (200.67 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.92 mM)
Smiles
OC1=CC=C (\C=C\C (=O) C2=CC=CC=C2) C=C1
Molecular Formula
C15H12O2
Molecular Weight
224.25
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

4-Hydroxychalcone

4-hydroxychalcone is a member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 4. It has a role as an antihypertensive agent and a plant metabolite. It is a member of chalcones and a member of phenols. It is functionally related to a trans-chalcone.

CAS Number20426-12-4
PubChem CID5282361
IUPAC Name(E)-3-(4-hydroxyphenyl)-1-phenylprop-2-en-1-one
Molecular FormulaC15H12O2
Molecular Weight224.25
XLogP2.7
Topological Polar Surface Area37.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Heavy Atom Count17
Formal Charge0
Complexity269
SMILES
C1=CC=C(C=C1)C(=O)/C=C/C2=CC=C(C=C2)O
InChI
InChI=1S/C15H12O2/c16-14-9-6-12(7-10-14)8-11-15(17)13-4-2-1-3-5-13/h1-11,16H/b11-8+
InChIKey
PWWCDTYUYPOAIU-DHZHZOJOSA-N
Chemical Structure
2D Structure
2D structure of 4-Hydroxychalcone
CAS: 20426-12-4
CID: 5282361
Formula: C15H12O2
MW: 224.25
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight224.25
XLogP32.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Exact Mass224.083729621
Monoisotopic Mass224.083729621
Topological Polar Surface Area37.3 Ų
Heavy Atom Count17
Formal Charge0
Complexity269
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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