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SOS1-IN-17

CAT: 0013-GTR19240992-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19240992-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SOS1-IN-17 (Compound 8d) is a potent, orally bioavailable SOS1 inhibitor that disrupts the SOS1-KRASG12C interaction (IC50 = 5.1 nM) . It effectively inhibits ERK phosphorylation and cellular proliferation in KRASG12C-mutant cancer cells and demonstrates in vivo antitumor activity in pancreatic cancer mouse models.
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Molecular Formula
C29H34F3N5O2
Molecular Weight
541.61
Storage Conditions
-20°C
Notes
For research use only.

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