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SOS1-IN-18

CAT: 0013-GTR19249225-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19249225-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SOS1-IN-18 (Compound 8) is a potent SOS1 inhibitor with a 2.6 nM K_D, disrupting the SOS1-KRAS G12C interaction (IC50 3.4 nM) . It demonstrates functional activity by inhibiting ERK phosphorylation (IC50 31 nM) and cellular proliferation (IC50 5 nM) in H358 cells, supporting its use in oncology research targeting the RAS/MAPK pathway.
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Molecular Formula
C26H29F3N4O2
Molecular Weight
486.53
Storage Conditions
-20°C
Notes
For research use only.

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