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PDL1 degrader-2

CAT: 0013-GTR19240466-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19240466-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PD-L1degrader-2 (Compound B3) is an orally active small molecule that induces PD-L1 degradation via the autophagy-lysosome pathway (DC50 = 0.5 μM) and blocks the PD-1/PD-L1 interaction (IC50 = 22.8 nM) . It demonstrates in vivo antitumor efficacy in CT26 mouse models, making it a useful tool for researching targeted protein degradation and cancer immunotherapy.
Field of Research
Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery
Molecular Formula
C45H48N8O5
Molecular Weight
780.91
Storage Conditions
-20°C
Notes
For research use only.

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