PD1-PDL1-IN 2

PD1-PDL1-IN 2

• CAS Number: 2566710-63-0
• UNSPSC Description: PD1-PDL1-IN 2 (ZE132) is a potent and selective PD-1/PD-L1 inhibitor, which has robust anti-tumour activity in vivo. PD1-PDL1-IN 2 promotes cytotoxic T-cell tumour infiltration and induces IL-2 expression. In addition, PD1-PDL1-IN 2 elicits strong inhibitory effects on the mRNA expression of TGF-β[1].
• Target Antigen: PD-1/PD-L1
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pd1-pdl1-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: N#CC1=CN=CC(COC2=CC(OCC3=CC=CC(C4=CC=C5OCCOC5=C4)=C3C)=C(C=C2CN(CCS(=O)(O)=O)CCCN(C)C)Cl)=C1
• Molecular Weight: 721.26
• References & Citations: [1]Liu C, et al. Discovery of a novel, potent and selective small-molecule inhibitor of PD-1/PD-L1 interaction with robust in vivo anti-tumour efficacy. Br J Pharmacol. 2021 Jul;178(13):2651-2670.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported