JG-23

• Description:

  JG-23 is a 4-chloro modified analog with ability to promote t-tau degradation. JG-23 exhibits good metabolic stability with a long T1/2 value (36 min) in mouse liver microsome assays[1].

• UNSPSC:

  12352005

• Target:

  Tau Protein

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/jg-23.html

• Purity:

  99.64

• Solubility:

  DMSO : 4.55 mg/mL (ultrasonic; warming; heat to 160°C)

• Smiles:

  CN1/C(SC2=CC=C(Cl)C=C21)=C3C(N(/C(S/3)=C/C4=CC=NC=C4)CC)=O

• Molecular Formula:

  C19H16ClN3OS2

• Molecular Weight:

  401.93

• References & Citations:

  [1]Shao H, et al. Inhibitors of heat shock protein 70 (Hsp70) with enhanced metabolic stability reduce tau levels. Bioorg Med Chem Lett. 2021 Jun 1;41:128025.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2640819-75-4