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JG-231

CAT: 0804-HY-124611-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-124611-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JG-231 is an allosteric inhibitor of heat shock protein 70 (Hsp70) . JG - 231 inhibits the binding of Hsp70 and BAG family proteins, including inhibition of Hsp70 and BAG1 with a Ki of 0.11 μM. JG-231 inhibits proliferation of tumor cells and induces apoptosis. JG-231 has antitumor activity[1][2].
CAS Number
1627126-59-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Apoptosis; HSP
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jg-231.html
Purity
98.47
Solubility
DMSO : 2 mg/mL (ultrasonic)
Smiles
O=C1N(CC)/C(S/C1=C2SC3=CC(Cl)=CC=C3N/2C)=C/C4=[N+](CC5=CC=C(Br)S5)C=CS4.[Cl-]
Molecular Formula
C22H18BrCl2N3OS4
Molecular Weight
619.47
Precautions
H302, H315, H319
References & Citations
[1]Shao H, et al. Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70) . J Med Chem. 2018 Jul 26;61 (14) :6163-6177. |[2]Hong SK, et al. Analogs of the Heat Shock Protein 70 Inhibitor MKT-077 Suppress Medullary Thyroid Carcinoma Cells. Int J Mol Sci. 2022 Jan 19;23 (3) :1063.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP70

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