JG-231

• Description:

  JG-231 is an allosteric inhibitor of heat shock protein 70 (Hsp70) . JG - 231 inhibits the binding of Hsp70 and BAG family proteins, including inhibition of Hsp70 and BAG1 with a Ki of 0.11 μM. JG-231 inhibits proliferation of tumor cells and induces apoptosis. JG-231 has antitumor activity[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319

• Target:

  Apoptosis; HSP

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/jg-231.html

• Purity:

  98.47

• Solubility:

  DMSO : 2 mg/mL (ultrasonic)

• Smiles:

  O=C1N(CC)/C(S/C1=C2SC3=CC(Cl)=CC=C3N/2C)=C/C4=[N+](CC5=CC=C(Br)S5)C=CS4.[Cl-]

• Molecular Formula:

  C22H18BrCl2N3OS4

• Molecular Weight:

  619.47

• Precautions:

  H302, H315, H319

• References & Citations:

  [1]Shao H, et al. Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70) . J Med Chem. 2018 Jul 26;61 (14) :6163-6177. |[2]Hong SK, et al. Analogs of the Heat Shock Protein 70 Inhibitor MKT-077 Suppress Medullary Thyroid Carcinoma Cells. Int J Mol Sci. 2022 Jan 19;23 (3) :1063.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  HSP70

• CAS Number:

  [1627126-59-3]